Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging.

@article{Vgh2012SynapticPC,
  title={Synaptic proteome changes in a DNA repair deficient ercc1 mouse model of accelerated aging.},
  author={Marlene J. V{\'e}gh and Monique C. de Waard and Ingrid van der Pluijm and Yanto Ridwan and Marion M. Sassen and Pim van Nierop and Roel C. van der Schors and Ka Wan Li and Jan H. J. Hoeijmakers and August Benjamin Smit and Ronald E van Kesteren},
  journal={Journal of proteome research},
  year={2012},
  volume={11 3},
  pages={
          1855-67
        }
}
  • Marlene J. Végh, Monique C. de Waard, +8 authors Ronald E van Kesteren
  • Published 2012
  • Biology, Medicine
  • Journal of proteome research
  • Cognitive decline is one of the earliest hallmarks of both normal and pathological brain aging. Here we used Ercc1 mutant mice, which are impaired in multiple DNA repair systems and consequently show accelerated aging and progressive memory deficits, to identify changes in the levels of hippocampal synaptic proteins that potentially underlie these age-dependent deficits. Aged Ercc1 mutant mice show normal gross hippocampal dendritic morphology and synapse numbers, and Ercc1 mutant hippocampal… CONTINUE READING

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    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 64 REFERENCES

    Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.