Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide

  title={Synaptic proteins. Characterization of tubulin and actin and identification of a distinct postsynaptic density polypeptide},
  author={P T Kelly and Carl Cotman},
  journal={The Journal of Cell Biology},
  pages={173 - 183}
The major proteins in isolated synaptic junctions (SJs) and postsynaptic densities (PSDs) have been compared to actin, tubulin, and the major neurofilament (NF) protein by two-dimensional gel electrophoresis and tryptic peptide map analysis. These studies show: (a) tubulin is present in SJ and PSD fractions and is identical to cytoplasmic tubulin, (b) actin in these fractions is very similar to the gamma- and beta-actin found predominantly in nonmuscle cells, and (c) the major PSD protein is… CONTINUE READING
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