Synaptic plasticity of kainate receptors.

@article{Mellor2006SynapticPO,
  title={Synaptic plasticity of kainate receptors.},
  author={Jack R. Mellor},
  journal={Biochemical Society transactions},
  year={2006},
  volume={34 Pt 5},
  pages={
          949-51
        }
}
  • J. Mellor
  • Published 1 October 2006
  • Biology
  • Biochemical Society transactions
Synaptic plasticity of ionotropic glutamate receptors has been extensively studied with a particular focus on the role played by NMDA (N-methyl-D-aspartate) receptors in the induction of synaptic plasticity and the subsequent movement of AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) receptors. The third subtype of ionotropic glutamate receptor, kainate receptors, has not been studied to the same extent, but recent evidence shows that these receptors also exhibit synaptic… 
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References

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It is demonstrated that high-frequency stimulation of mossy fibres in rat hippocampal slices, in the presence of the highly selective AMPA receptor antagonist GYKI 53655, plus NMDA- and GABA-receptor antagonists, activates an inward current in CA3 neurons that has a pharmacology typical of kainate receptors.
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It is reported that repetitive activation of the hippocampal mossy fibre pathway, which is associated with high-affinity kainate binding and many of the kainATE receptor subtypes, generates a slow excitatory synaptic current with all of the properties expected of a kainates receptor.
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TLDR
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