Synaptic plasticity in the rat striatum following chronic haloperidol treatment.

@article{Kerns1992SynapticPI,
  title={Synaptic plasticity in the rat striatum following chronic haloperidol treatment.},
  author={James M Kerns and Diane K Sierens and L C Kao and Harold L. Klawans and Paul M. Carvey},
  journal={Clinical neuropharmacology},
  year={1992},
  volume={15 6},
  pages={488-500}
}
Administration of the dopamine (DA) antagonist haloperidol leads to the development of behavioral hypersensitivity as well as enhanced neuronal growth when striatal extracts from these animals are incubated with mesencephalic cultures. For determining if alterations in neuronal growth also occur in vivo, the ultrastructure of the neuropil in the dorsolateral quadrant of the striatum from rats treated (24 days) with haloperidol (1.25 mg/kg) was examined by electron microscopy. Haloperidol… CONTINUE READING
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