Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse.

@article{Chen2010SynapticPI,
  title={Synaptic plasticity in the mesolimbic system: therapeutic implications for substance abuse.},
  author={Billy Chen and Frederic Woodward Hopf and Antonello Bonci},
  journal={Annals of the New York Academy of Sciences},
  year={2010},
  volume={1187},
  pages={129-39}
}
In an ever-changing environment, animals must learn new behavioral strategies for the successful procurement of food, sex, and other needs. Synaptic plasticity within the mesolimbic system, a key reward circuit, affords an animal the ability to adapt and perform essential goal-directed behaviors. Ironically, drugs of abuse can also induce synaptic changes within the mesolimbic system, and such changes are hypothesized to promote deleterious drug-seeking behaviors in lieu of healthy, adaptive… CONTINUE READING

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