Synaptic plasticity in the hippocampus is modulated by behavioral state.

@article{Bramham1989SynapticPI,
  title={Synaptic plasticity in the hippocampus is modulated by behavioral state.},
  author={Clive R Bramham and Bolek Srebro},
  journal={Brain research},
  year={1989},
  volume={493 1},
  pages={74-86}
}
The possible influence of the sleep-waking cycle on evoked neurotransmission and on the induction of long-term potentiation (LTP) and depression (LTD) was studied in the perforant path-granule cell system. Freely moving rats received a high-frequency stimulus train (8 bursts at 400 Hz) during slow-wave sleep (SWS), rapid eye movement (REM) sleep, and a still-alert (SAL) behavioral state. Trains applied during SAL and REM reliably elicited LTP of the excitatory postsynaptic potential (EPSP… CONTINUE READING

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