Synaptic plasticity in drug reward circuitry.

  title={Synaptic plasticity in drug reward circuitry.},
  author={Danny G. Winder and Regula E. Egli and Nicole L. Schramm and Robert T Matthews},
  journal={Current molecular medicine},
  volume={2 7},
Drug addiction is a major public health issue worldwide. The persistence of drug craving coupled with the known recruitment of learning and memory centers in the brain has led investigators to hypothesize that the alterations in glutamatergic synaptic efficacy brought on by synaptic plasticity may play key roles in the addiction process. Here we review the present literature, examining the properties of synaptic plasticity within drug reward circuitry, and the effects that drugs of abuse have… CONTINUE READING


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