Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice.

Abstract

Amyloid-β (Aβ)-induced changes in synaptic function in experimental models of Alzheimer's disease (AD) suggest that Aβ generation and accumulation may affect fundamental mechanisms of synaptic plasticity. To test this hypothesis, we examined the effect of APP overexpression on a well characterized, in vivo, developmental model of systems-level plasticity… (More)
DOI: 10.1523/JNEUROSCI.5369-11.2012

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