Synaptic plasticity and addiction

@article{Kauer2007SynapticPA,
  title={Synaptic plasticity and addiction},
  author={J. Kauer and R. Malenka},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={844-858}
}
  • J. Kauer, R. Malenka
  • Published 2007
  • Psychology, Medicine
  • Nature Reviews Neuroscience
  • Addiction is caused, in part, by powerful and long-lasting memories of the drug experience. Relapse caused by exposure to cues associated with the drug experience is a major clinical problem that contributes to the persistence of addiction. Here we present the accumulated evidence that drugs of abuse can hijack synaptic plasticity mechanisms in key brain circuits, most importantly in the mesolimbic dopamine system, which is central to reward processing in the brain. Reversing or preventing… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Paper Mentions

    BLOG POST
    Glutamate transmission in addiction
    • 280
    • PDF
    Drug-Evoked Synaptic Plasticity in Addiction: From Molecular Changes to Circuit Remodeling
    • 727
    • PDF
    Synaptic plasticity and addiction: Learning mechanisms gone awry
    • 77
    • PDF
    The glutamate homeostasis hypothesis of addiction
    • 912
    Cellular basis of memory for addiction
    • 152
    • PDF
    14 CH 8003 BA_INTERIEUR.qxd:DCNS#55
    • 2013

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 189 REFERENCES