Synaptic plasticity: taming the beast

  title={Synaptic plasticity: taming the beast},
  author={L. F. Abbott and Sacha B. Nelson},
  journal={Nature Neuroscience},
  volume={3 Suppl 1},
Synaptic plasticity provides the basis for most models of learning, memory and development in neural circuits. To generate realistic results, synapse-specific Hebbian forms of plasticity, such as long-term potentiation and depression, must be augmented by global processes that regulate overall levels of neuronal and network activity. Regulatory processes are often as important as the more intensively studied Hebbian processes in determining the consequences of synaptic plasticity for network… 
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These forms of plasticity not only share common learning rules and induction pathways with the better known synaptic plasticity but may also contribute in synergy with these synaptic changes to the formation of a coherent mnesic engram.
Biophysics-Based Models of LTP/LTD
A feature of synaptic plasticity is the bidirectionality, which is the capability to increase or decrease the synaptic weights, thus encompassing the classical Hebbian paradigm.
Synaptic Plasticity and Memory
The question of how memories can persist despite ongoing synaptic plasticity is still unresolved, and this " plasticity­ stability dilemma " is lately becoming an important focus of research on synaptic physiology.
Homeostatic plasticity in the developing nervous system
Evidence is discussed from a number of systems that homeostatic synaptic plasticity is crucial for processes ranging from memory storage to activity-dependent development, and how these processes maintain stable activity states in the face of destabilizing forces is discussed.
Homeostatic plasticity—a presynaptic perspective
Synaptic plasticity, metaplasticity and BCM theory.
There does appear to be a good correspondence of the synaptic plasticity and metaplasticity experimental data with the Bienenstock, Cooper and Munro model.
Inhibitory Plasticity: From Molecules to Computation and Beyond
This work focuses on the molecular pathways involved in the induction and expression mechanisms leading to changes in synaptic efficacy, and discusses, from the computational perspective, how IP can contribute to the emergence of functional properties of brain circuits.


Redistribution of synaptic efficacy between neocortical pyramidal neurons
It is shown that an increase in the synaptic response, induced by pairing action-potential activity in pre- and postsynaptic neurons, was only observed when synaptic input occurred at low frequencies, and arises because of a redistribution of the available synaptic efficacy.
Competitive Hebbian learning through spike-timing-dependent synaptic plasticity
In modeling studies, it is found that this form of synaptic modification can automatically balance synaptic strengths to make postsynaptic firing irregular but more sensitive to presynaptic spike timing.
A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons
Action potentials provide a synaptically controlled, associative signal to the dendrites for Hebbian modifications of synaptic strength and induced a robust LTP in CA1 neurons.
The role of dendritic filtering in associative long-term synaptic plasticity.
It is suggested here that both spike train attenuation in the dendrite and its modulation by neurotransmitters and electrical activity may have important functional consequences on the magnitude and/or the sign of the synaptic plasticity induced by a Hebbian pairing procedure.
Activity-dependent scaling of quantal amplitude in neocortical neurons
A new form of synaptic plasticity is described that increases or decreases the strength of all of a neuron's synaptic inputs as a function of activity, and may help to ensure that firing rates do not become saturated during developmental changes in the number and strength of synaptic inputs.
Metaplasticity: A new vista across the field of synaptic plasticity
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs.
Synaptic Depression and the Temporal Response Characteristics of V1 Cells
The effects of short-term synaptic depression on the temporal dynamics of V1 responses to visual images is explored by constructing a model simple cell that matches both extracellular and intracellular data.
Distinct Functional Types of Associative Long-Term Potentiation in Neocortical and Hippocampal Pyramidal Neurons
  • D. Buonomano
  • Biology, Psychology
    The Journal of Neuroscience
  • 1999
There are distinct forms of associative LTP and that the different forms may reflect the underlying computations taking place in different areas, as well as suggesting that in the cortex LTP may preferentially amplify stimulus onset.