Synaptic plasticity, place cells and spatial memory: study with second generation knockouts

@article{Wilson1997SynapticPP,
  title={Synaptic plasticity, place cells and spatial memory: study with second generation knockouts},
  author={Matthew A. Wilson and Susumu Tonegawa},
  journal={Trends in Neurosciences},
  year={1997},
  volume={20},
  pages={102-106}
}
The use of genetically engineered mice has been a major development in neuroscience research. Genetic engineering is an undoubtedly powerful technique; however, the value of this approach has been debated, particularly in relation to its use to probe the underlying bases of complex behaviors, such as memory. A recent new development of the technique is the ability to target a specific gene knockout to a particular subregion or even to specific and limited cell types of the mouse brain. An… CONTINUE READING
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