Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele

@article{Blennow1996SynapticPI,
  title={Synaptic pathology in Alzheimer's disease: Relation to severity of dementia, but not to senile plaques, neurofibrillary tangles, or the ApoE4 allele},
  author={K Blennow and Nenad Bogdanovi{\'c} and Irina Alafuzoff and Rolf Ekman and Pia Davidsson},
  journal={Journal of Neural Transmission},
  year={1996},
  volume={103},
  pages={603-618}
}
Alzheimer's disease (AD) is characterised by an increased number of senile plaques (SP) and neuroflbrillary tangles (NFT) as compared with that found in non-demented individuals of the same age, and a marked degeneration and loss of synapses. One of the main risk-factors for the disorder is inheritance of the apolipoprotein E4 (ApoE4) allele. To further study the relation between these pathogenetic substrates for AD, we quantified the synaptic vesicle membrane protein rab3a in brain tissue from… CONTINUE READING
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