Synaptic modulation by astrocytes via Ca2+-dependent glutamate release

@article{Santello2009SynapticMB,
  title={Synaptic modulation by astrocytes via Ca2+-dependent glutamate release},
  author={Mirko Santello and Andrea Volterra},
  journal={Neuroscience},
  year={2009},
  volume={158},
  pages={253-259}
}
Gliotransmission and the tripartite synapse.
TLDR
By releasing gliotransmitters in millisecond time scale with a specific vesicular apparatus, astrocytes can integrate and process synaptic information and control or modulate synaptic transmission and plasticity.
Neurotransmitters and Integration in Neuronal-Astroglial Networks
Two major neural cell types, glia, astrocytes in particular, and neurones can release chemical transmitters that act as soluble signalling compounds for intercellular communication. Exocytosis, a
ASTROCYTE-MEDIATED SHORT-TERM SYNAPTIC DEPRESSION
TLDR
It is found that the PBD develops over the first three postnatal weeks and that it is blocked when astrocyte metabolism is compromised, suggesting thatAstrocytes are critically involved in mediating a negative feedback on synaptic transmission after a burst of synaptic activity.
Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes
TLDR
Evidence questioning Ca2+-dependent gliotransmitter release from astrocytes in healthy brain tissue is examined, followed by a close examination of recent work suggesting that Ca2-dependentgliotransmitters release occurs as an early event in the development of neurological disorders and neuroinflammatory and neurodegenerative diseases.
CXCR4-mediated glutamate exocytosis from astrocytes
New tools for investigating astrocyte-to-neuron communication
TLDR
Some limitations of conventional methodologies are discussed and the interest of novel tools and approaches for studying gliotransmission are highlighted and emerging perspectives on the complexity of astrocyte Ca2+ signaling revealed by GECIs are discussed.
Astrocytes—The Ultimate Effectors of Long-Range Neuromodulatory Networks?
TLDR
The hypothesis that astrocytes extend and amplify neuromodulatory influences on neuronal networks via alterations in calcium dynamics, the release of gliotransmitters, and potassium homeostasis is explored.
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