Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice.

@article{Pilpel2009SynapticIG,
  title={Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice.},
  author={Yair Pilpel and Aleksander Kolleker and Sven Berberich and Melanie Ginger and Andreas Frick and Edwin Mientjes and Ben A. Oostra and P. H. Seeburg},
  journal={The Journal of physiology},
  year={2009},
  volume={587 Pt 4},
  pages={787-804}
}
Fragile X syndrome is one of the most common forms of mental retardation, yet little is known about the physiological mechanisms causing the disease. In this study, we probed the ionotropic glutamate receptor content in synapses of hippocampal CA1 pyramidal neurons in a mouse model for fragile X (Fmr1 KO2). We found that Fmr1 KO2 mice display a significantly lower AMPA to NMDA ratio than wild-type mice at 2 weeks of postnatal development but not at 6-7 weeks of age. This ratio difference at 2… CONTINUE READING

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