Synaptic functions of endocannabinoid signaling in health and disease.

@article{Araque2017SynapticFO,
  title={Synaptic functions of endocannabinoid signaling in health and disease.},
  author={Alfonso Araque and Pablo E Castillo and Olivier J Manzoni and Raffaella Tonini},
  journal={Neuropharmacology},
  year={2017},
  volume={124},
  pages={
          13-24
        }
}
Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of synaptic transmission and plasticity. They are synthetized "on demand" following physiological and/or pathological stimuli. Once released from postsynaptic neurons, eCBs typically act as retrograde messengers to activate presynaptic type 1 cannabinoid receptors (CB1) and induce short- or long-term depression of neurotransmitter release. Besides this canonical mechanism of action, recent findings have revealed… CONTINUE READING
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