Synaptic efficacy enhanced by glial cells in vitro.

@article{Pfrieger1997SynapticEE,
  title={Synaptic efficacy enhanced by glial cells in vitro.},
  author={F. Pfrieger and Barbara A. Barres},
  journal={Science},
  year={1997},
  volume={277 5332},
  pages={
          1684-7
        }
}
In the developing nervous system, glial cells guide axons to their target areas, but it is unknown whether they help neurons to establish functional synaptic connections. The role of glial cells in synapse formation and function was studied in cultures of purified neurons from the rat central nervous system. In glia-free cultures, retinal ganglion cells formed synapses with normal ultrastructure but displayed little spontaneous synaptic activity and high failure rates in evoked synaptic… 

Regional variations in the glial influence on synapse development in the mouse CNS

The results indicate that in the mammalian CNS, the way that glial signals promote the development of excitatory synapses depends on the type of neuron.

Schwann cells and astrocytes induce synapse formation by spinal motor neurons in culture

Control of synapse number by glia.

It is shown that few synapses form in the absence of glial cells and that the fewsynapses that do form are functionally immature, and that CNS synapse number can be profoundly regulated by nonneuronal signals.

Glial cells promote dendrite formation and the reception of synaptic input in Purkinje cells from postnatal mice

The results reinforce the idea that glial cells promote synaptogenesis in specific neuronal cell types by indicating that dendrite development is necessary but not sufficient for PCs to receive excitatory synaptic input and thatsynaptogenesis requires additional signals.

Glial cells in synaptic plasticity

Glia-neuron interactions in nervous system function and development.

  • S. Shaham
  • Biology
    Current topics in developmental biology
  • 2005

Roles of glial cells in synapse development

  • F. Pfrieger
  • Biology
    Cellular and Molecular Life Sciences
  • 2009
Recent evidence that synapse development is not a cell-autonomous process and that its distinct phases depend on assistance from the so-called glial cells is summarized.

Differential Dependence of GABAergic and Glutamatergic Neurons on Glia for the Establishment of Synaptic Transmission

A fundamental difference is demonstrated in the way GABAergic and glutamatergic neurons depend on glia for the establishment of synaptic transmission, a finding that has important implications for the understanding of how neuronal networks develop.
...

References

SHOWING 1-10 OF 15 REFERENCES

Cell recognition by neuronal growth cones in a simple vertebrate embryo

Laser ablation experiments support the hypothesis that early growth cones that pioneer specific spinal tracts appear to recognize cues on subsets of longitudinally arrayed neuroepithelial cells and demonstrate that later growth cone that selectively fasciculate in these spinal tracts seem to recognizing cues on specific subset of axons.

Neuron/glia relationships observed over intervals of several months in living mice

The present results suggest that glial cells are involved in synaptic remodeling, in accord with the recent observation that synapses on these neurons are normally subject to ongoing rearrangement.

New views on synapse—glia interactions

Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue

These preparations should significantly aid in efforts to examine the biochemistry, physiology, and pharmacology of these two major classes of central nervous system cells.

Quantal analysis of synaptic potentials in neurons of the central nervous system.

The major topics covered in this review are the properties of the quantal synaptic potential and the junctional mechanisms involved in its generation.

An evaluation of causes for unreliability of synaptic transmission.

  • C. AllenC. Stevens
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1994
Probabilistic release mechanisms at low capacity synapses are the main cause of unreliability of synaptic transmission on CA1 hippocampal pyramidal neurons.

Axonal guidance during development of the great cerebral commissures: Descriptive and experimental studies, in vivo, on the role of preformed glial pathways

During normal ontogeny of the mouse forebrain and before the arrival of the pioneer fibers of the corpus callosum at the midline, a population of primitive glial cells migrates medially (through the fused walls of the dorsal septum) from the ependymal zones of each hemisphere.