Synaptic dysfunction in depression: potential therapeutic targets.


Basic and clinical studies demonstrate that depression is associated with reduced size of brain regions that regulate mood and cognition, including the prefrontal cortex and the hippocampus, and decreased neuronal synapses in these areas. Antidepressants can block or reverse these neuronal deficits, although typical antidepressants have limited efficacy and… (More)
DOI: 10.1126/science.1222939


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