Synaptic depression and neuronal loss in transiently acidic hippocampal slice cultures

@article{Xiang2000SynapticDA,
  title={Synaptic depression and neuronal loss in transiently acidic hippocampal slice cultures},
  author={Z Xiang and Peter J Bergold},
  journal={Brain Research},
  year={2000},
  volume={881},
  pages={77-87}
}
Acidosis is a rapid and inevitable event accompanying cerebral ischemia or trauma. We used hippocampal slice cultures to examine an immediate effect of acidosis, synaptic depression; and a delayed effect, neuronal loss. Exposure to low bicarbonate artificial cerebral spinal fluid (aCSF), pH 6.70 for 30 min at 32 degrees C, acidified intracellular pH from 7.31+/-0.12 to 6.53+/-0.08. Accompanying intracellular acidosis was a depression of synaptic responses. Both effects rapidly reversed after… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 28 references

Acidosis - related damage , Adv . Thompson , Organotypic slice cultures : a technique has come of age

  • R. A. McKinney, B. K. Siesjo, K. Katsura, T. Kristian
  • Exp . Neurol .
  • 2000

Intracellular covery in a tissue culture model of ischemia

  • K. Shimoji
  • J . Neurosci . Meth .
  • 2000

Spreading depressionlike Staub , Effect of lactacidosis on cell volume and intracellular pH of hypoxic depolarization in CA 1 and fascia dentata of hippocampal astrocytes

  • J. Peters, I. Kolbl, A. Baethmann, P. G. Aitken, G. G. Somjen
  • J . Neurotrauma
  • 1999

Acid - Association Grantinaid to P . J . B . induced death in neurons and glia

  • S. A. Goldman M. Nedergaard, S. Desai, W. A. Pulsinelli
  • J . Neurosci .
  • 1997

Stability of brain obligatory aerobic energy substrate for functional recovery after intracellular lactate and 31 Pmetabolitelevels at reduced intracellular hypoxia : further in vitro validation

  • L. H. Chang, J. W. Severinghaus, +6 authors T. L. James
  • Brain Res .
  • 1997

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