Synaptic density of the prefrontal cortex regulated by dopamine instead of serotonin in rats.

@article{Sugahara1998SynapticDO,
  title={Synaptic density of the prefrontal cortex regulated by dopamine instead of serotonin in rats.},
  author={Masayuki Sugahara and Hideyuki Shiraishi},
  journal={Brain research},
  year={1998},
  volume={814 1-2},
  pages={143-56}
}
Recent findings indicate that monoamine contributes to synaptic plasticity. We examined the synaptic density of the prefrontal cortex and parietal cortex of rats using dopamine (DA) antagonists and agonists, as well as serotonin (5-HT) depleters and found a reduction in synaptic density in the prefrontal cortex lamina V-VI at a maximum of 20% with administration of a D1 antagonist (SCH23390) and at a maximum of 30% with a D2 antagonist (YM09151). Further, with the administration of D1+D2… CONTINUE READING