Synaptic computation underlying probabilistic inference

@article{Soltani2010SynapticCU,
  title={Synaptic computation underlying probabilistic inference},
  author={Alireza Soltani and Xiao-Jing Wang},
  journal={Nature Neuroscience},
  year={2010},
  volume={13},
  pages={112-119}
}
We propose that synapses may be the workhorse of the neuronal computations that underlie probabilistic reasoning. We built a neural circuit model for probabilistic inference in which information provided by different sensory cues must be integrated and the predictive powers of individual cues about an outcome are deduced through experience. We found that bounded synapses naturally compute, through reward-dependent plasticity, the posterior probability that a choice alternative is correct given… CONTINUE READING

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