Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity.

@article{Fellous2003SynapticBN,
  title={Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity.},
  author={J. M. Fellous and Michelle Rudolph and Alain Destexhe and Terrence J. Sejnowski},
  journal={Neuroscience},
  year={2003},
  volume={122 3},
  pages={811-29}
}
In vivo, in vitro and computational studies were used to investigate the impact of the synaptic background activity observed in neocortical neurons in vivo. We simulated background activity in vitro using two stochastic Ornstein-Uhlenbeck processes describing glutamatergic and GABAergic synaptic conductances, which were injected into a cell in real time using the dynamic clamp technique. With parameters chosen to mimic in vivo conditions, layer 5 rat prefrontal cortex cells recorded in vitro… CONTINUE READING
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