Synaptic assembly of the brain in the absence of neurotransmitter secretion.

@article{Verhage2000SynapticAO,
  title={Synaptic assembly of the brain in the absence of neurotransmitter secretion.},
  author={Matthijs Verhage and Ascanio S. Maia and Jaap J. Plomp and Arjen Brussaard and Joost H Heeroma and Hendrika Vermeer and Ruud F.G. Toonen and Robert Hammer and Timo K van den Berg and Markus Missler and Hans J. Geuze and Thomas C S{\"u}dhof},
  journal={Science},
  year={2000},
  volume={287 5454},
  pages={864-9}
}
Brain function requires precisely orchestrated connectivity between neurons. Establishment of these connections is believed to require signals secreted from outgrowing axons, followed by synapse formation between selected neurons. Deletion of a single protein, Munc18-1, in mice leads to a complete loss of neurotransmitter secretion from synaptic vesicles throughout development. However, this does not prevent normal brain assembly, including formation of layered structures, fiber pathways, and… CONTINUE READING
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