Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein.

@article{Yao2002SynapticAN,
  title={Synaptic and nuclear localization of brain-enriched guanylate kinase-associated protein.},
  author={Ikuko Yao and Junko Iida and Wataru Nishimura and Yutaka Hata},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 13},
  pages={5354-64}
}
Brain-enriched guanylate kinase-associated protein (BEGAIN) interacts with postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90. In immunohistochemistry and immunocytochemistry, BEGAIN was detected in nuclei and at synapses in neurons. Nuclear localization was also confirmed through subcellular fractionation. BEGAIN was localized exclusively in nuclei when expressed in epithelial cells. These findings led us to analyze the mechanism to determine the subcellular localization of… CONTINUE READING