Synaptic amplifier of inflammatory pain in the spinal dorsal horn.

@article{Ikeda2006SynapticAO,
  title={Synaptic amplifier of inflammatory pain in the spinal dorsal horn.},
  author={Hiroshi Ikeda and Johanna K. Stark and Harald Fischer and M W Wagner and Ruth Drdla and Tino Jaeger and J{\"u}rgen Sandk{\"u}hler},
  journal={Science},
  year={2006},
  volume={312 5780},
  pages={
          1659-62
        }
}
Inflammation and trauma lead to enhanced pain sensitivity (hyperalgesia), which is in part due to altered sensory processing in the spinal cord. The synaptic hypothesis of hyperalgesia, which postulates that hyperalgesia is induced by the activity-dependent long-term potentiation (LTP) in the spinal cord, has been challenged, because in previous studies of pain pathways, LTP was experimentally induced by nerve stimulation at high frequencies ( approximately 100 hertz). This does not, however… CONTINUE READING

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