Synaptic adhesion molecules in Cadm family at the neuromuscular junction.

@article{Tanabe2013SynapticAM,
  title={Synaptic adhesion molecules in Cadm family at the neuromuscular junction.},
  author={Yuko Tanabe and Eriko Fujita and Yukiko K. Hayashi and Xinran Zhu and Hermann Lubbert and Yoshihiro Mezaki and Haruki Senoo and Takashi Momoi},
  journal={Cell biology international},
  year={2013},
  volume={37 7},
  pages={731-6}
}
RA175/SynCAM1/Cadm1 (Cadm1), a member of the immunoglobulin superfamily, is a synaptic cell adhesion molecule that has a PDZ-binding motif at the C-terminal region. It promotes the formation of presynaptic terminals and induces functional synapses in the central nervous system. Cadm1-deficient (knockout [KO]) mice show behavioral abnormalities, including excessive aggression and anxiety, but do not show any symptoms of neuromuscular disorder, although neuromuscular junctions (NMJs) have… CONTINUE READING

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