Synaptic adhesion molecules in Cadm family at the neuromuscular junction

@article{Tanabe2013SynapticAM,
  title={Synaptic adhesion molecules in Cadm family at the neuromuscular junction},
  author={Y. Tanabe and E. Fujita and Y. Hayashi and X. Zhu and Hermann Lubbert and Y. Mezaki and H. Senoo and T. Momoi},
  journal={Cell Biology International},
  year={2013},
  volume={37}
}
  • Y. Tanabe, E. Fujita, +5 authors T. Momoi
  • Published 2013
  • Medicine, Biology
  • Cell Biology International
  • RA175/SynCAM1/Cadm1 (Cadm1), a member of the immunoglobulin superfamily, is a synaptic cell adhesion molecule that has a PDZ‐binding motif at the C‐terminal region. It promotes the formation of presynaptic terminals and induces functional synapses in the central nervous system. Cadm1‐deficient (knockout [KO]) mice show behavioral abnormalities, including excessive aggression and anxiety, but do not show any symptoms of neuromuscular disorder, although neuromuscular junctions (NMJs) have… CONTINUE READING
    Cadms/SynCAMs/Necls/TSLCs Interact with Multi-PDZ Domain Protein MUPP1
    1
    Necl‐4/Cadm4 recruits Par‐3 to the Schwann cell adaxonal membrane
    2

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