Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

@inproceedings{Inoue2009SynapticAP,
  title={Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation},
  author={Eiji Inoue and Maki Deguchi-Tawarada and Aki Togawa and Chiyuki Matsui and Kohei Arita and Sayaka Katahira-Tayama and Toshitaka Sato and Emiko Yamauchi and Yoshiya Oda and Yoshimi Takai},
  booktitle={The Journal of cell biology},
  year={2009}
}
Alzheimer's disease is an age-dependent neurodegenerative disorder that is characterized by a progressive decline in cognitive function. gamma-secretase dysfunction is evident in many cases of early onset familial Alzheimer's disease. However, the mechanism by which gamma-secretase dysfunction results in memory loss and neurodegeneration is not fully understood. Here, we demonstrate that gamma-secretase is localized at synapses and regulates spine formation. We identify EphA4, one of the Ephrin… CONTINUE READING

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