Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.

@article{Bottai2002SynapticAC,
  title={Synaptic activity-induced conversion of intronic to exonic sequence in Homer 1 immediate early gene expression.},
  author={Daniele Bottai and John F. Guzowski and Martin Karl Schwarz and Shin H Kang and Bo Xiao and Anthony A. Lanahan and Paul F Worley and P. H. Seeburg},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 1},
  pages={167-75}
}
Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR5 and their coupling to releasable intracellular Ca2+ pools and ion channels. Only the Homer 1 gene evolved bimodal expression of constitutive (Homer 1b and c) and immediate early gene (IEG) products (Homer 1a and Ania 3). The IEG forms compete functionally with the constitutive Homer proteins. The complex expression of the Homer 1 gene, unique for IEGs, focused our attention on the gene organization… CONTINUE READING

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