Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons.

  title={Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons.},
  author={Christopher M. Bocchiaro and Jack L Feldman},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 12},
Potentiation and depression of glutamate receptor function in hippocampal, cerebellar, and cortical neurons are examples of persistent changes in synaptic function that underlie important behavioral adaptations such as learning and memory. Persistent changes in synaptic function relevant for motor behaviors have not been demonstrated in mammalian motoneurons. We demonstrate that adaptive changes in (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide (AMPA) receptor… CONTINUE READING


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