Synaptic Vesicle Pools at the Frog Neuromuscular Junction

@article{Richards2003SynapticVP,
  title={Synaptic Vesicle Pools at the Frog Neuromuscular Junction},
  author={David A. Richards and Cristina Guatimosim and Silvio O Rizzoli and William J. Betz},
  journal={Neuron},
  year={2003},
  volume={39},
  pages={529-541}
}
We have characterized the morphological and functional properties of the readily releasable pool (RRP) and the reserve pool of synaptic vesicles in frog motor nerve terminals using fluorescence microscopy, electron microscopy, and electrophysiology. At rest, about 20% of vesicles reside in the RRP, which is depleted in about 10 s by high-frequency nerve stimulation (30 Hz); the RRP refills in about 1 min, and surprisingly, refilling occurs almost entirely by recycling, not mobilization from the… CONTINUE READING
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