Synaptic Theory of Working Memory

@article{Mongillo2008SynapticTO,
  title={Synaptic Theory of Working Memory},
  author={Gianluigi Mongillo and Omri Barak and Misha Tsodyks},
  journal={Science},
  year={2008},
  volume={319},
  pages={1543 - 1546}
}
It is usually assumed that enhanced spiking activity in the form of persistent reverberation for several seconds is the neural correlate of working memory. Here, we propose that working memory is sustained by calcium-mediated synaptic facilitation in the recurrent connections of neocortical networks. In this account, the presynaptic residual calcium is used as a buffer that is loaded, refreshed, and read out by spiking activity. Because of the long time constants of calcium kinetics, the… Expand
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