Synaptic Refractory Period Provides a Measure of Probability of Release in the Hippocampus

@article{Hjelmstad1997SynapticRP,
  title={Synaptic Refractory Period Provides a Measure of Probability of Release in the Hippocampus},
  author={Gregory O Hjelmstad and Roger A Nicoll and Robert C Malenka},
  journal={Neuron},
  year={1997},
  volume={19},
  pages={1309-1318}
}
Despite extensive research, much controversy remains regarding the locus of expression of long-term potentiation (LTP) in area CA1 of the hippocampus, specifically, whether LTP is accompanied by an increase in the probability of release (p(r)) of synaptic vesicles. We have developed a novel method for assaying p(r), which utilizes the synaptic refractory period--a brief 5-6 ms period following release during which the synapse is incapable of transmission (Stevens and Wang, 1995). We show that… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 60 references

Calciuminflux and transmitter external 3and 4aminopyridine

  • J. G. G. Borst, B. Sakmann
  • Biophys . J . Nature
  • 1996
1 Excerpt

Similar Papers

Loading similar papers…