Synaptic Pruning in Development: A Computational Account

  title={Synaptic Pruning in Development: A Computational Account},
  author={Gal Chechik and Isaac Meilijson and Eytan Ruppin},
  journal={Neural Computation},
Research with humans and primates shows that the developmental course of the brain involves synaptic overgrowth followed by marked selective pruning. Previous explanations have suggested that this intriguing, seemingly wasteful phenomenon is utilized to remove erroneous synapses. We prove that this interpretation is wrong if synapses are Hebbian. Under limited metabolic energy resources restricting the amount and strength of synapses, we show that memory performance is maximized if synapses are… CONTINUE READING

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