Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.

@article{Trimbuch2009SynapticPM,
  title={Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling.},
  author={Thorsten Trimbuch and Prateep Beed and Johannes Vogt and Sebastian Schuchmann and Nikolaus Maier and Michael Kintscher and Joerg Breustedt and Markus Schuelke and Nora Streu and Olga Kieselmann and Irene Brunk and Gregor Laube and Ulf Strauss and Arne Battefeld and Hagen Wende and Carmen Birchmeier and Stefan. Wiese and Michael Sendtner and Hiroshi Kawabe and Mika Kishimoto-Suga and Nils Brose and Jan Baumgart and Beate Geist and Junken Aoki and Nic E. Savaskan and Anja U Br{\"a}uer and Jerold Chun and Olaf Ninnemann and Dietmar Schmitz and Robert Stefan Nitsch},
  journal={Cell},
  year={2009},
  volume={138 6},
  pages={
          1222-35
        }
}
Plasticity related gene-1 (PRG-1) is a brain-specific membrane protein related to lipid phosphate phosphatases, which acts in the hippocampus specifically at the excitatory synapse terminating on glutamatergic neurons. Deletion of prg-1 in mice leads to epileptic seizures and augmentation of EPSCs, but not IPSCs. In utero electroporation of PRG-1 into deficient animals revealed that PRG-1 modulates excitation at the synaptic junction. Mutation of the extracellular domain of PRG-1 crucial for… CONTINUE READING
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