Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior.

@article{Li2015SynapticPS,
  title={Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior.},
  author={Jun Li and Anping Chai and Lifang Wang and Yuanlin Ma and Zhiliu Wu and Hao Yu and Liwei Mei and Lin Lu and Chen Zhang and Weihua Yue and Lin Huao Xu and Yi Rao and Dai Jing Zhang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 50},
  pages={E6964-72}
}
Autism spectrum disorders (ASDs) are a group of highly inheritable mental disorders associated with synaptic dysfunction, but the underlying cellular and molecular mechanisms remain to be clarified. Here we report that autism in Chinese Han population is associated with genetic variations and copy number deletion of P-Rex1 (phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1). Genetic deletion or knockdown of P-Rex1 in the CA1 region of the hippocampus in mice resulted in… CONTINUE READING
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