The role of the actin cytoskeleton in regulating Drosophila behavior
- BiologyReviews in the neurosciences
Recent advances in Drosophila that highlight the importance of actin regulatory proteins in mediating fly behaviors such as circadian rhythm, courtship behavior, learning and memory, and the development of drug addiction are discussed.
Dissecting the role of adducin in the axonal cytoskeleton
It is hypothesized that adducin might be involved in the organization and/or plasticity of the AIS that requires actin dynamics, and in α-adducin KO animals, which do not have the ability to relocate it in response to chronic depolarization.
The conserved microRNA miR-34 regulates synaptogenesis via coordination of distinct mechanisms in presynaptic and postsynaptic cells
- BiologyNature Communications
An unbiased screen for novel regulators of synapse morphogenesis at the Drosophila larval neuromuscular junction discovered that miR-34 inhibits Nrx-IV to influence active zone formation, whereas, postsynaptic miR -34 inhibits Hts to regulate the initiation of bouton formation from presynaptic terminals.
Sez6l2 regulates phosphorylation of ADD and neuritogenesis.
- BiologyBiochemical and biophysical research communications
Scale Invariant Disordered Nanotopography Promotes Hippocampal Neuron Development and Maturation with Involvement of Mechanotransductive Pathways
- BiologyFront. Cell. Neurosci.
It is reported that nanostructured zirconia surfaces, produced by supersonic cluster beam deposition of zirConia nanoparticles and characterized by ECM-like nanotopographical features, can direct the maturation of neural networks.
Proteomic Analysis of Mouse Cortex Postsynaptic Density following Neonatal Brain Hypoxia-Ischemia
- BiologyDevelopmental Neuroscience
Insight is provided into the biochemical changes of PSDs following early brain hypoxia-ischemia, which is helpful for understanding not only the injury mechanisms, but also the process of repair or replenishment of neuronal circuits during recovery from brain damage.
Decoding the Synaptic Proteome with Long-Term Exposure to Midazolam during Early Development
- BiologyInternational journal of molecular sciences
New information is shed on the long-term exposure of MDZ during the early stages of development impacts synaptic function, which could subsequently perturb neurobehavioral outcomes at later stages of life.
ADDing a piece to the puzzle of cognition in schizophrenia.
- PsychologyEuropean journal of medical genetics
Musical practice and BDNF plasma levels as a potential marker of synaptic plasticity: an instrument of rehabilitative processes
- Biology, MedicineNeurological Sciences
Assuming BDNF PLs to be a marker of synaptic plasticity, higher PLs could be associated with the activation of alternative neural pathways: a lower score in the “attention to detail” sub-scale could imply greater flexibility of higher cerebral functions among musicians.
Definition of the early HIV-1 signalosome in dendritic cells
A multipronged experimental approach based on phosphoproteomics, transcriptomics and custom RNAi screen was developed to characterize the early signaling complex induced by HIV-1 in DCs and identifies novel mechanism of the immune evasion tactics usurped byAIDS.
SHOWING 1-10 OF 36 REFERENCES
Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)
- BiologyPLoS biology
A novel signaling cascade controlling actin polymerization in response to extracellular signals regulates filopodia formation and likely also neuronal synapse formation.
Hts/Adducin Controls Synaptic Elaboration and Elimination
Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein
- BiologyThe Journal of Neuroscience
Results indicate that β-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.
β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment
β‐adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the α‐ and γ‐adducin subunits
- Biology, PsychologyGenes, brain, and behavior
The results strongly suggest coordinated expression and phosphorylation of adducin subunits as a key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.
A New Function for Adducin CALCIUM/CALMODULIN-REGULATED CAPPING OF THE BARBED ENDS OF ACTIN FILAMENTS*
- Biology, Chemistry
A novel function is demonstrated for adducin; it completely blocks elongation and depolymerization at the barbed (fast growing) ends of actin filaments, thus functioning as a barbed end capping protein (Kcap ;100 nM).
Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
It is shown that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.
Adducin: structure, function and regulation
- Biology, ChemistryCellular and Molecular Life Sciences CMLS
Calmodulin, gelsolin and phosphorylation by the kinase inhibit in vitro activities of adducin involving actin and spectrin, suggesting a role for adduc in cell motility, and as a target for regulation by Rho-dependent and Ca2+-dependent pathways.
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton
- Biology, ChemistryProceedings of the National Academy of Sciences of the United States of America
Evidence is provided for a critical role of actin in recycling of synaptic vesicle recycling, which seems to involve functions both in endocytosis and in the transport of recycled vesicles to the synapticvesicle cluster.
Experience-dependent structural synaptic plasticity in the mammalian brain
- BiologyNature Reviews Neuroscience
Recent evidence for structural forms of synaptic plasticity in the mammalian cortex involves cell type-specific structural plasticity: some boutons and dendritic spines appear and disappear, accompanied by synapse formation and elimination, respectively.