Synaptic Growth: Dancing with Adducin

@article{Stevens2011SynapticGD,
  title={Synaptic Growth: Dancing with Adducin},
  author={Robin J. Stevens and J. Troy Littleton},
  journal={Current Biology},
  year={2011},
  volume={21},
  pages={R402-R405}
}
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References

SHOWING 1-10 OF 36 REFERENCES
Eps8 Regulates Axonal Filopodia in Hippocampal Neurons in Response to Brain-Derived Neurotrophic Factor (BDNF)
A novel signaling cascade controlling actin polymerization in response to extracellular signals regulates filopodia formation and likely also neuronal synapse formation.
Hts/Adducin Controls Synaptic Elaboration and Elimination
Impaired Synaptic Plasticity and Learning in Mice Lacking β-Adducin, an Actin-Regulating Protein
TLDR
Results indicate that β-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory.
β-Adducin Is Required for Stable Assembly of New Synapses and Improved Memory upon Environmental Enrichment
β‐adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the α‐ and γ‐adducin subunits
TLDR
The results strongly suggest coordinated expression and phosphorylation of adducin subunits as a key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.
A New Function for Adducin CALCIUM/CALMODULIN-REGULATED CAPPING OF THE BARBED ENDS OF ACTIN FILAMENTS*
TLDR
A novel function is demonstrated for adducin; it completely blocks elongation and depolymerization at the barbed (fast growing) ends of actin filaments, thus functioning as a barbed end capping protein (Kcap ;100 nM).
Rab3A is essential for mossy fibre long-term potentiation in the hippocampus
TLDR
It is shown that, although a variety of short-term plasticities are normal, LTP at mossy fibre synapses is abolished in mice lacking the synaptic vesicle protein Rab3A.
Adducin: structure, function and regulation
TLDR
Calmodulin, gelsolin and phosphorylation by the kinase inhibit in vitro activities of adducin involving actin and spectrin, suggesting a role for adduc in cell motility, and as a target for regulation by Rho-dependent and Ca2+-dependent pathways.
Impaired recycling of synaptic vesicles after acute perturbation of the presynaptic actin cytoskeleton
TLDR
Evidence is provided for a critical role of actin in recycling of synaptic vesicle recycling, which seems to involve functions both in endocytosis and in the transport of recycled vesicles to the synapticvesicle cluster.
Experience-dependent structural synaptic plasticity in the mammalian brain
TLDR
Recent evidence for structural forms of synaptic plasticity in the mammalian cortex involves cell type-specific structural plasticity: some boutons and dendritic spines appear and disappear, accompanied by synapse formation and elimination, respectively.
...
...