Synaptic GABAA receptor clustering without the γ2 subunit.

@article{KertiSzigeti2014SynapticGR,
  title={Synaptic GABAA receptor clustering without the γ2 subunit.},
  author={Katalin Kerti-Szigeti and Zoltan Nusser and Mark D Eyre},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2014},
  volume={34 31},
  pages={10219-33}
}
Rapid activation of postsynaptic GABAA receptors (GABAARs) is crucial in many neuronal functions, including the synchronization of neuronal ensembles and controlling the precise timing of action potentials. Although the γ2 subunit is believed to be essential for the postsynaptic clustering of GABAARs, synaptic currents have been detected in neurons obtained from γ2(-/-) mice. To determine the role of the γ2 subunit in synaptic GABAAR enrichment, we performed a spatially and temporally… CONTINUE READING

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