Synaptic GABAA activation induces Ca2+ rise in pyramidal cells and interneurons from rat neonatal hippocampal slices.

@article{Leinekugel1995SynapticGA,
  title={Synaptic GABAA activation induces Ca2+ rise in pyramidal cells and interneurons from rat neonatal hippocampal slices.},
  author={Xavier Leinekugel and Vadim Tseeb and Yehezkel Ben-Ari and Piotr Bregestovski},
  journal={The Journal of physiology},
  year={1995},
  volume={487 ( Pt 2)},
  pages={319-29}
}
1. Changes in intracellular Ca2+ concentration ([Ca2+]i) induced by activation of GABAA receptors (synaptic stimulation or application of the GABAA agonist isoguvacine) were studied on pyramidal cells and interneurons from hippocampal slices of rats from two age groups (postnatal days (P) 2-5 and P12-13) using the fluorescent dye fluo-3 and a confocal laser scanning microscope. Cells were loaded with the dye either intracellularly, using patch pipettes containing fluo-3 in the internal solution… CONTINUE READING
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