Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning: Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice

@inproceedings{Yao2011SynapticEL,
  title={Synaptic E3 Ligase SCRAPPER in Contextual Fear Conditioning: Extensive Behavioral Phenotyping of Scrapper Heterozygote and Overexpressing Mutant Mice},
  author={Ikuko Yao and Keizo Takao and Tsuyoshi Miyakawa and Seiji Ito and Mitsutoshi Setou},
  booktitle={PloS one},
  year={2011}
}
SCRAPPER, an F-box protein coded by FBXL20, is a subunit of SCF type E3 ubiquitin ligase. SCRAPPER localizes synapses and directly binds to Rab3-interacting molecule 1 (RIM1), an essential factor for synaptic vesicle release, thus it regulates neural transmission via RIM1 degradation. A defect in SCRAPPER leads to neurotransmission abnormalities, which could subsequently result in neurodegenerative phenotypes. Because it is likely that the alteration of neural transmission in Scrapper mutant… CONTINUE READING
Highly Cited
This paper has 139 citations. REVIEW CITATIONS
16 Citations
78 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

139 Citations

050100'13'15'17
Citations per Year
Semantic Scholar estimates that this publication has 139 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Similar Papers

Loading similar papers…