Synaptic Dysbindin-1 Reductions in Schizophrenia Occur in an Isoform-Specific Manner Indicating Their Subsynaptic Location

@inproceedings{Talbot2011SynapticDR,
  title={Synaptic Dysbindin-1 Reductions in Schizophrenia Occur in an Isoform-Specific Manner Indicating Their Subsynaptic Location},
  author={Konrad Talbot and Natalia Louneva and Julia W. Cohen and Hala Altaf Kazi and Derek J Blake and Steven E Arnold},
  booktitle={PloS one},
  year={2011}
}
BACKGROUND An increasing number of studies report associations between variation in DTNBP1, a top candidate gene in schizophrenia, and both the clinical symptoms of the disorder and its cognitive deficits. DTNBP1 encodes dysbindin-1, reduced levels of which have been found in synaptic fields of schizophrenia cases. This study determined whether such synaptic reductions are isoform-specific. METHODOLOGY/PRINCIPAL FINDINGS Using Western blotting of tissue fractions, we first determined the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 34 extracted citations

Dysbindin-1 Involvement in the Etiology of Schizophrenia

International journal of molecular sciences • 2017
View 3 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 85 references

Dysbindin-1 and its protein family with special attention to the potential role of dysbindin-1 in neuronal functions and the pathophysiology of schizophrenia

K Talbot, WY Ong, DJ Blake, J Tang, N Louneva
Javitt D, Kantrowitz J, eds. Handbook of neurochemistry and molecular neurobiology, • 2009
View 6 Excerpts
Highly Influenced

Association study of NRG1, DTNBP1, RGS4, G72/G30, and PIP5K2A with schizophrenia and symptom severity in a Hungarian sample.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2010
View 1 Excerpt

Auditory Cortex Anatomy and Asymmetry in Schizophrenia

JF Smiley
2009

Similar Papers

Loading similar papers…