Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss

  title={Synaptic Consolidation Normalizes AMPAR Quantal Size following MAGUK Loss},
  author={Jonathan M Levy and Xiaobing Chen and Thomas S. Reese and Roger A Nicoll},
The mechanisms controlling synapse growth and maintenance are of critical importance for learning and memory. The MAGUK family of synaptic scaffolding proteins is abundantly expressed at glutamatergic central synapses, but their importance in controlling the synaptic content of glutamate receptors is poorly understood. Here, we use a chained RNAi-mediated knockdown approach to simultaneously remove PSD-93, PSD-95, and SAP102, the MAGUKs previously shown to be responsible for synaptic… CONTINUE READING
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Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

  • Y. Takumi, V. Ramı́rez-León, P. Laake, E. Rinvik, O. P. Ottersen
  • Nat. Neurosci
  • 1999
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