Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation.

@article{Zetka1999SynapsisAC,
  title={Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation.},
  author={Monique C. Zetka and Ichiro Kawasaki and Susan Strome and Fritz M{\"u}ller},
  journal={Genes & development},
  year={1999},
  volume={13 17},
  pages={2258-70}
}
Meiotic chromosomes are organized about a proteinaceous core that forms between replicated sister chromatids. We have isolated a Caenorhabditis elegans gene, him-3, which encodes a meiosis-specific component of chromosome cores with some similarity to the yeast lateral element protein Hop1p. Antibodies raised against HIM-3 localize the protein to condensing chromosomes in early prophase I and to the cores of both synapsed and desynapsed chromosomes. In RNA interference experiments, chromosomes… CONTINUE READING
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