Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.

@article{Hosaka1998SynapsinsIA,
  title={Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.},
  author={Masahiro Hosaka and Thomas C S{\"u}dhof},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 3},
  pages={1425-9}
}
Synapsins I and II are abundant phosphoproteins that are localized to synaptic vesicles and have essential functions in regulating synaptic vesicle exocytosis. Synapsins contain a single evolutionarily conserved, large central domain, the C-domain, that accounts for the majority of their sequences. Unexpectedly, the crystal structure of the C-domain from synapsin I revealed that it is structurally closely related to several ATPases despite the absence of sequence similarities (Esser, L., Wang… CONTINUE READING

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