Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity.

@article{Onofri1997SynapsinII,
  title={Synapsin I interacts with c-Src and stimulates its tyrosine kinase activity.},
  author={Franco Onofri and Silvia Gioved{\`i} and Paola Vaccaro and Andrew J. Czernik and Flavia Valtorta and Pietro De Camilli and Paul Greengard and Fabio Benfenati},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 22},
  pages={12168-73}
}
Synapsin I is a synaptic vesicle-associated phosphoprotein that has been implicated in the formation of presynaptic specializations and in the regulation of neurotransmitter release. The nonreceptor tyrosine kinase c-Src is enriched on synaptic vesicles, where it accounts for most of the vesicle-associated tyrosine kinase activity. Using overlay, affinity chromatography, and coprecipitation assays, we have now shown that synapsin I is the major binding protein for the Src homology 3 (SH3… CONTINUE READING

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