Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system

@article{Takei1995SynapsinID,
  title={Synapsin I deficiency results in the structural change in the presynaptic terminals in the murine nervous system},
  author={Yusuke Takei and Akihiro Harada and Shiunichi Takeda and Kohta Kobayashi and Sumio Terada and Takeshi Noda and Tomoyuki Takahashi and Nobutaka Hirokawa},
  journal={The Journal of Cell Biology},
  year={1995},
  volume={131},
  pages={1789 - 1800}
}
Synapsin I is one of the major synaptic vesicle-associated proteins. Previous experiments implicated its crucial role in synaptogenesis and transmitter release. To better define the role of synapsin I in vivo, we used gene targeting to disrupt the murine synapsin I gene. Mutant mice lacking synapsin I appeared to develop normally and did not have gross anatomical abnormalities. However, when we examined the presynaptic structure of the hippocampal CA3 field in detail, we found that the sizes of… CONTINUE READING

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