Synapse specificity of long-term potentiation breaks down with aging.

@article{Ris2007SynapseSO,
  title={Synapse specificity of long-term potentiation breaks down with aging.},
  author={Laurence Ris and Emile Godaux},
  journal={Learning & memory},
  year={2007},
  volume={14 3},
  pages={185-9}
}
Memory shows age-related decline. According to the current prevailing theoretical model, encoding of memories relies on modifications in the strength of the synapses connecting the different cells within a neuronal network. The selective increases in synaptic weight are thought to be biologically implemented by long-term potentiation (LTP). Here, we report that tetanic stimulation of afferent fibers in slices from 12-mo-old mice triggers an LTP not restricted to the activated synapses. This… CONTINUE READING