Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala

  title={Synapse-specific reconsolidation of distinct fear memories in the lateral amygdala},
  author={Val{\'e}rie Doy{\`e}re and Jacek Debiec and Marie H Monfils and Glenn E. Schafe and Joseph E LeDoux},
  journal={Nature Neuroscience},
When reactivated, memories enter a labile, protein synthesis–dependent state, a process referred to as reconsolidation. Here, we show in rats that fear memory retrieval produces a synaptic potentiation in the lateral amygdala that is selective to the reactivated memory, and that disruption of reconsolidation is correlated with a reduction of synaptic potentiation in the lateral amygdala. Thus, both retrieval and reconsolidation alter memories via synaptic plasticity at selectively targeted… 

Learning and reconsolidation implicate different synaptic mechanisms

It is reported that synapses in projections to the lateral nucleus of the amygdala implicated in auditory fear conditioning, which are potentiated by learning, enter a labile state after memory reactivation, and must be restabilized through a postsynaptic mechanism implicating the mammalian target of rapamycin kinase-dependent signaling.

The Amygdala Encodes Specific Sensory Features of an Aversive Reinforcer

Exposure to the unconditionsed stimulus initiates an unconditioned stimulus−specific reconsolidation of learned fear in rats that depended on the amygdala, and specific features of the unconditional stimulus appear to be encoded in the amygdala as part of fear memories stored there.

Proton receptors regulate synapse-specific reconsolidation in the amygdala

It is discovered that CO2 inhalation paired with memory retrieval potentiates the specific aversive memory trace, resulting in greater memory lability, and inhaling CO2 during the retrieval event increases the lability of an aversiveMemory through a synapse-specific reconsolidation process.

Sensory-Specific Associations Stored in the Lateral Amygdala Allow for Selective Alteration of Fear Memories

It is shown in rats that fear memory reactivation through presentation of the aversive US, like CS presentation, triggers a process which, when disrupted, results in a selective depotentiation ofCS-evoked neural responses in the LA in correlation with a selective suppression of CS-elicited fear memory.

Behavioural memory reconsolidation of food and fear memories

To confirm that reactivation followed by extinction reflects a behavioural analog of memory reconsolidation, it is shown that prevention of contextual fear memory reactivation by the LVGCC blocker nimodipine interferes with the amnestic outcome.

Molecular mechanisms of memory reconsolidation

Understanding the molecular mechanisms of reconsolidation could provide crucial insights into the dynamic aspects of normal mnemonic function and psychiatric disorders that are characterized by exceptionally strong and salient emotional memories.

The selectivity of aversive memory reconsolidation and extinction processes depends on the initial encoding of the Pavlovian association

Using a compound stimulus in which two distinct CSs are concomitantly paired with the same aversive unconditioned stimulus (US), it is shown in rats that reexposure to one of the components of the compound CS triggers extinction or reconsolidation of the other component.



Tracking the Fear Engram: The Lateral Amygdala Is an Essential Locus of Fear Memory Storage

This work combines site-specific behavioral pharmacology with multisite electrophysiological recording techniques to show that the lateral nucleus of the amygdala, long thought to be critical for the acquisition of fear memories, is also an essential locus of fear memory storage.

Directly reactivated, but not indirectly reactivated, memories undergo reconsolidation in the amygdala.

It is found that directly reactivated memories become labile, but indirectly reactivated (i.e., associated) memories do not, which suggests that memory reactivation produces content-limited rather than wholesale changes in a memory and its associations and explains why each time a memory is retrieved and updated, the entire associative structure of the memory is not grossly altered.

Amnesia or retrieval deficit? Implications of a molecular approach to the question of reconsolidation.

This article will propose that two experimental approaches involving the targeting of specific molecular mechanisms, and the study of these mechanisms during retrieval, may serve useful to the field as it is now able to advance beyond comparisons between consolidation and reconsolidation.

Fear conditioning induces associative long-term potentiation in the amygdala

It is shown that fear conditioning alters auditory CS-evoked responses in LA in the same way as LTP induction, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience.

Reconsolidation: the advantage of being refocused

  • Y. Dudai
  • Psychology
    Current Opinion in Neurobiology
  • 2006

Retrieval and reconsolidation: toward a neurobiology of remembering.

  • S. Sara
  • Biology, Psychology
    Learning & memory
  • 2000
The theoretical emphasis on memory reactivation and reconsolidation made here raises the issue, as yet ill addressed by neurobiological experiments, of factors that control or modulate these processes.

Emotion Circuits in the Brain

The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially