Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease.

@article{Bigio2003SynapseLM,
  title={Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease.},
  author={Eileen Bigio and Joan S. Reisch and Charles L. White and Sivapong Satumtira and Estelle Sontag and Frederick J. Bonte},
  journal={Dementia and geriatric cognitive disorders},
  year={2003},
  volume={15 2},
  pages={72-8}
}
In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results… CONTINUE READING