Synapse formation on neurons born in the adult hippocampus

@article{Toni2007SynapseFO,
  title={Synapse formation on neurons born in the adult hippocampus},
  author={Nicolas Toni and E Matthew Teng and Eric A. Bushong and James B. Aimone and Chunmei Zhao and Antonella Consiglio and Henriette van Praag and Maryann E. Martone and Mark Ellisman and Fred H. Gage},
  journal={Nature Neuroscience},
  year={2007},
  volume={10},
  pages={727-734}
}
Although new and functional neurons are produced in the adult brain, little is known about how they integrate into mature networks. Here we explored the mechanisms of synaptogenesis on neurons born in the adult mouse hippocampus using confocal microscopy, electron microscopy and live imaging. We report that new neurons, similar to mature granule neurons, were contacted by axosomatic, axodendritic and axospinous synapses. Consistent with their putative role in synaptogenesis, dendritic filopodia… 
Pre-existing astrocytes form functional perisynaptic processes on neurons generated in the adult hippocampus
TLDR
Results indicate that pre-existing astrocytes remodel their processes to ensheathe synapses of adult-born neurons and participate to the functional and structural integration of these cells into the hippocampal network.
Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain
TLDR
Using retrovirus-mediated birth-dating and labeling and serial section electron microscopic reconstruction, mossy fiber en passant boutons of adult-born dentate granule cells form initial synaptic contacts with CA3 pyramidal cells within 2 weeks after their birth and reach morphologic maturity within 8 weeks in the adult hippocampus.
Neurons born in the adult dentate gyrus form functional synapses with target cells
TLDR
Structural and functional evidence indicates that axons of adult-born granule cells establish synapses with hilar interneurons, mossy cells and CA3 pyramidal cells and release glutamate as their main neurotransmitter.
Synapse formation on adult‐born hippocampal neurons
TLDR
This work reviews the current knowledge on the development of the synaptic input and output of neurons born in the adult hippocampus, from the stem/progenitor cell to the fully mature neuron and provides insight on the regulation of adult neurogenesis by some neurotransmitters.
Development of Adult-Generated Cell Connectivity with Excitatory and Inhibitory Cell Populations in the Hippocampus
TLDR
A combined connectivity analysis of the output connections of adult-born hippocampal cells is used to show that, as these cells integrate into hippocampal circuits, they transiently form strong connections with local inhibitory circuits.
Age-Related Changes in Synaptic Plasticity Associated with Mossy Fiber Terminal Integration during Adult Neurogenesis
TLDR
Maturation of mossy fiber bouton (MFB) connectivity with CA3 pyramidal cells in young adult and aged mouse brain is described and suggested elimination of preexisting connectivity is required for the integration of adult-born GCs in aged brain.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 53 REFERENCES
Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus
TLDR
It is proposed that neurons born in the developing and adult hippocampus constitute a functionally homogeneous neuronal population, and that adult-born neurons can fire action potentials in response to an excitatory drive.
Spine growth precedes synapse formation in the adult neocortex in vivo
TLDR
The data show that spine growth precedes synapse formation and that new synapses form preferentially onto existing boutons, and in some instances, two new spines contacted the same axon.
Synaptogenesis on mature hippocampal dendrites occurs via filopodia and immature spines during blocked synaptic transmission
TLDR
Reconstruction from serial section electron microscopy suggests that synaptogenesis and spine formation are readily initiated under conditions of reduced activity in the mature brain.
Remodeling of Synaptic Structure in Sensory Cortical Areas In Vivo
TLDR
The data suggest that changes in network function during adult learning and memory might occur through changes in the strength and efficacy of existing synapses as well as some remodeling of connectivity through the loss and gain of synapses.
Distinct Morphological Stages of Dentate Granule Neuron Maturation in the Adult Mouse Hippocampus
TLDR
The study reveals the key morphological transitions of newborn granule neurons during their course of maturation and shows that the morphological maturation is differentially affected by age and experience, as shown by comparisons between adult and postnatal brains and between housing conditions.
Neuronal Differentiation in the Adult Hippocampus Recapitulates Embryonic Development
TLDR
It is striking that neuronal maturation in the adult hippocampus follows a precise sequence of connectivity (silent → slow GABA → glutamate → fast GABA) that resembles hippocampal development.
Functional neurogenesis in the adult hippocampus
TLDR
It is reported that newly generated cells in the adult mouse hippocampus have neuronal morphology and can display passive membrane properties, action potentials and functional synaptic inputs similar to those found in mature dentate granule cells.
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
TLDR
The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
Neurogenesis in the adult is involved in the formation of trace memories
TLDR
It is shown that a substantial reduction in the number of newly generated neurons in the adult rat impairs hippocampal-dependent trace conditioning, a task in which an animal must associate stimuli that are separated in time.
NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
TLDR
A retrovirus-mediated, single-cell gene knockout technique in mice is developed and it is shown that the survival of new neurons is competitively regulated by their own NMDA-type glutamate receptor during a short, critical period soon after neuronal birth, indicating that thesurvivors and the resulting formation of new circuits are regulated in an input-dependent, cell-specific manner.
...
1
2
3
4
5
...