Synapse formation occurs in association with the induction of long-term potentiation in two-year-old rat hippocampus in vitro.

Following induction of long-term potentiation in subfield CA1 of the hippocampal slice from 26-month-old rats, shaft synapse numbers increased by 44% and sessile spine synapses (synapses on stubby, headless spines) by 72%, with the more common mushroom-shaped spine synapses statistically unaltered. These effects are smaller than in prior work with young… CONTINUE READING