Synapse formation is regulated by the signaling adaptor GIT1

  title={Synapse formation is regulated by the signaling adaptor GIT1},
  author={Huaye Zhang and Donna J. Webb and Hannelore Asmussen and Alan F. Horwitz},
  journal={The Journal of Cell Biology},
  pages={131 - 142}
Dendritic spines in the central nervous system undergo rapid actin-based shape changes, making actin regulators potential modulators of spine morphology and synapse formation. Although several potential regulators and effectors for actin organization have been identified, the mechanisms by which these molecules assemble and localize are not understood. Here we show that the G protein-coupled receptor kinase-interacting protein (GIT)1 serves such a function by targeting actin regulators and… CONTINUE READING
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